• Used for severe asthma that doesn't improve with inhaled corticosteroids or other long-term asthma medications
• Treatment performed through the working channel of a standard flexible bronchoscope
• Involves heating the airways with an electrode, reducing the smooth muscle inside the airways
• Limits the ability of the airways to tighten
Bronchial thermoplasty is performed through the working channel of a standard flexible bronchoscope that is introduced through a patient’s nose or mouth, and into their lungs. Under sedation, a catheter inside a bronchoscope—a thin, flexible tube-like instrument introduced through the patient’s nose or mouth, and into their lungs. The tip of the small diameter catheter is expanded to contact the walls of targeted airways. Controlled thermal energy is then delivered to the airway walls to reduce the presence of excess airway smooth muscle that narrows the airways in patients with asthma.
The catheter delivers a series of 10-second temperature-controlled bursts of radiofrequency energy, which heat the lining of the lungs to 65 degrees Celsius. This heat destroys some of the muscle tissue that constricts during an asthma attack, reducing the number and severity of incidents. The patient is monitored after the procedure and usually returns home that day or early the next day.
In the period immediately following bronchial thermoplasty, the most common side effect is an expected transient increase in the frequency and worsening of respiratory-related symptoms, which are of the type expected following bronchoscopy in patients with asthma. These events typically occur within a day of the procedure and resolve on average within seven days with standard care.
The New Pulmogenix Solution: Bronchial Smooth Muscle Modification
PulmoGeniX™ is developing a comprehensive device-based treatment intended to diagnose and treat asthma. The technology was invented to reduce bronchial smooth muscle to eliminate its ability to constrict and, thus, dramatically decrease asthma attacks. It is designed to treat a greater number of airways simultaneously, to be less technically challenging for the physician, to be performed within one procedural visit, and to be less expensive for the patient.
After therapy is delivered, the electrically conductive fluid is withdrawn. The chamber is then filled with methyl choline. The methyl Choline is intended to incite an asthmatic spasm of the bronchial smooth muscle. The Pulmotonometer is then used to, once again, measure the relative levels of spasticity of the smooth muscle. This post-therapy measurement is then compared to the pre-therapy diagnostic measurement to evaluate treatment efficacy.